NOW ON KINDLE: The Corona Conspiracy: Combatting Disinformation about the Coronavirus “Very useful in this time when wild, unsupported ideas are flying everywhichway.” (David Quammen)

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Frank Visser, graduated as a psychologist of culture and religion, founded IntegralWorld in 1997. He worked as production manager for various publishing houses and as service manager for various internet companies and lives in Amsterdam. Books: Ken Wilber: Thought as Passion (SUNY, 2003), and The Corona Conspiracy: Combatting Disinformation about the Coronavirus (Kindle, 2020).

PCR-Gate 2:
When Lockdown Skeptics Pose as Expert Scientists

The Corona Conspiracy, Part 24

Frank Visser

"There is also no confusion with other viruses, other cold viruses, other coronaviruses or anything else for pathogens. There is simply no room for these discussions. The PCR is simply beyond doubt." (Christian Drosten).

We will again touch upon the topic of the so-called "PCR-Gate", involving a retraction request of an early paper on the SARS-CoV-2 test protocol (see Part 20).[1] As it turned out, this retraction did not materialize, much to the chagrin of the main authors of this Corman-Drosten Review Report[2] and has caused another round of allegations and accusations regarding the policies of regular science. Though any scientific misconduct and conflicts of interest were denied by Eurosurveillance, this did not convince these authors in the least. On the contrary, they doubled down in their conviction that science had to be liberated from politics and the review processes used by science needed to become more transparant than ever.

In this Part 24 of our THE CORONA CONSPIRACY series we will show, however, that this exalted self-image of the Review Report authors as representing good science leaves a lot to be desired. The authors asked for input on their ten main points of criticism, and we will go into this in greater detail here as well.

As the saying goes, be careful what you ask for.

BROADCASTING CORONAVIRUS DISINFORMATION

As an example of how some of the main contributors of the Review Report spread disinformation about science, I first want to point to a YouTube video in which author and journalist Naomi Wolf interviewed Kevin McKernan and Bobby Malhotra.[3]

The discussion aims at an entry level audience (so a lot of times the basics of the PCR test are explained, usually with other technical terms that will bedazzle the laymen), but here and there some scientific statements are made about the Corman-Drosten test. The interviewer expresses her astonishment with the fact the the Corman-Drosten team did not have the SARS-CoV-2 virus at their disposal at this early stage of the pandemic, and yet claimed to have a test that could detect this pathogen, among other "Asian coronaviruses". Now, any PCR or sequencing expert would instantly correct this layman understanding, but McKernan and Malhotra merely reinforce it.

Wolf: His [Christian Drostens] goal was to create, his stated goal, the author's stated goal, was to create a test that could detect a virus when the virus wasn't present. And in addition to that he didn't have virus, coronavirus, COVID-19 to work with, right?
Malhotra: [Nods]
Wolf: He was drawing a sequence from a computer database. Is all of that correct?
McKernan: Yes, I would say, say he had an intention to pick up the virus when it was present but in his design he admitted that he couldn't do a very good job with imperfect information and it would pick up other Asian coronaviruses.
Wolf: And that it would pick up other Asian coronaviruses...
McKernan: Yes.
Wolf: And when you say 'pick up' meaning the test would indicate, return a positive, yes, if there were other coronaviruses. And for the lay person, I didn't know this either, everything is a coronavirus, I mean... many cold viruses are also called 'coronavirus'. In fact, Covid-19 sounded so exotic and scary when we first learned about a corona virus, but many ordinary cold viruses are corona viruses, is that correct?
McKernan: It's correct, there's four that we watch very closely, HKU1 is a name of one, uh OC40, I think it's 43, and NL63 and NL229 [sic]. Those are the four ones that are commonly tracked but there's in fact thousands of them.

Wolf: The authors said in their paper: we can't guarantee that this will return a positive that doesn't also pick up other Asian cold viruses, is that correct?
McKernan: Yes, that's correct.
Wolf: Alright, pick up again Bobby please from there...
Malhotra: Yeah so to pick up from there, he [Drosten) sent his prototype PCR test to Hong Kong... and by luck it gave a positive test result and immediately Christian Drosten sent over his protocol to the WHO and also to Eurosurveillance and because he was very happy about it that it was positive. And yeah it was all a little bit of a guessing game in this case.
Wolf: So basically there's no way to know if that first historic positive PCR test was some Asian person with a cold or someone with an early detected COVID-19 case, is that correct?
Malhotra: It is correct, yeah I would say, it is correct.

Wolf: So basically it's not a casual step or gilding the lily. It's an absolutely essential final step [of] sequencing to make sure that what looks like it could be Covid-19 but it could also be a bunch of other asian cold viruses which we all get whether we're in asia or not...
McKernan: Right.
Wolf: ... they go around the world. That last step of sequencing to make sure this is Covid-19 was not taken, is that correct?
McKernan: Not in the PCR protocol that he utilized.

McKernan: In the draft or the text of their paper, they demonstrate that... they knew that they would pick up other viruses...
Wolf: Woooww! (9:00-14:00)

The grossly misguided picture presented here is that the Corman-Drosten test was created merely without having the SARS-CoV-2 virus at their disposal, but intentionally set up so vague as to pick up other Asian coronaviruses, and that this means we are never sure that if your test is positive you have COVID-19 or just the common cold. However, what in the Corman-Drosten paper is meant by "Asian viruses" were bat viruses! Duh. Here's the relevant paragraph titled "Detection range for SARS-related coronaviruses from bats."

Nor was there any cross-reactivity with all the known "common cold" viruses:

What is wrong with this admittedly popularizing video of the Consortium authors?

First, the fact that the virus was not available at the time the test protocol was created is not a problem, because the virual sequence of SARS-CoV-2 was available, as it was shared to the Corman-Drosten team by the Chinese. By comparing this sequence with other SARS-related viruses which are stored in a large database, it became apparent very soon that this was a new SARS-CoV virus.

Second, even though this virus was a very specific one, the test was intentionally set up in a more generic way, because of the previous experience with SARS-CoV. After all, the pandemic was still in its early days and coronaviruses tend to mutate as they spread. But this would not be a problem since SARS-CoV or bat viruses are at present not circulating in humans, as Drosten was quick to point out.[2]. A specific test for SARS-CoV-2 was added as well.

And third, and most importantly, this did not mean that the viruses that cause the common cold were included. In fact, the Corman-Drosten paper clearly and unambiguously states that these four "common" coronaviruses were tested against as a test for cross-reactivity, and they specifically conclude, after having tested 22(!) known respiratory viruses, "None of the tested viruses or virus preparations showed reactivity with any assay."[1]

As you can clearly see, the four common cold viruses mentioned by McKernan to cast doubt on the effectiveness of the Corman-Drosten test and on the integrity of its authors were at the very top of the tests done for cross-reactivity. If this is the type of "science" advocated by this team of "top scientists", we are really in deep trouble. This is a slanderous and grossly misinformed interpretation of what the Corman-Drosten protocol really intends to accomplish—and has accomplished.

It's no use going deeper into this video, but this is what I found when analyzing only 5 minutes. You see the clear pattern of distortion and disinformation.

Taxonomic classification of the SARS-CoV-2 virus

Here is the family tree of the coronaviruses for your convenience and education. As you can see the four common cold viruses mentioned in the video and the Corman-Drosten paper belong to completely different types or subgroups of coronaviruses:

Phylogenetic tree of coronaviruses. Relative positions of HCoV (human coronavirus) viruses and SARS-CoV. Note: SARS-CoV and SARS-CoV-2 both belong to the same species called "SARSr-CoV" or "SARS-related coronavirus (Wikipedia).

The "other" coronaviruses the Corman-Drosten test matches all belong to Subgroup B: sarbecoviruses. This consists of SARS-CoV, SARS-CoV-2, and two bat viruses: Bat SL-CoV-WIV1 and RaTG13. This does not make this test "completely aspecific" (Borger) for SARS-CoV-2. This can be demonstrated also by showing its taxonomical location.

Here's the official phylogenetic tree of coronaviruses, from the Coronaviridae Study Group of the International Committee on Taxonomy of Viruses[3a]:

In the traditional taxonomic hierarchy, this is where we find the new SARS-CoV-2 virus (Wikipedia):

So just remember, SARS-CoV-2 belongs indeed to the very large family of the coronaviruses, but has nothing to do with the common cold. Different genus, different subgenus, different species, different strain. The Corman-Drosten test specifically aims at the SARS-related coronavirus species, catching several of its strains.

This is basic virological knowledge which even Wikipedia can teach you, but which is lost on conspiracy-minded pseudo-scientists like McKernan and Mahlhotra (not to mention sensationalist authors/journalists who feed on them like Naomi Klein).

If anything is "garbage" it is these two gentlemen's understanding of coronaviruses. They are wildly off by three taxonomic levels.

TIME TO LET CHRISTIAN DROSTEN HAVE HIS SAY...

It is unfortunate—though perhaps understandable—that none of the Corman-Drosten paper authors has dealt with the Review Report points of criticism—that I must grant to their disgruntled authors. Obviously, the tone of voice of the Review Report didn't invite any such discussion and possibly alienated parts of their potential audience (though with an alleged 20 million page views, that audience has been extremely large for a "scientific" paper). Yet Christian Drosten has appeard in German media frequently in the past twelve months, and in this March 2020 fragment from the Norddeutscher Rundfunk radio he discusses similar concerns about his PCR test:

Christian Drosten

Korinna Hennig: The critical voices, in particular the quoted Wolfgang Wodarg, also relate directly to the PCR test, i.e. the genetic test for the virus that you and your team have developed and that is used worldwide. It has not been validated at all, i.e. has been adequately scientifically assessed, and has not been created at all on the basis of the current SARS-CoV-2 genome and would therefore also display everything else possible. Can you briefly explain to us how you established the PCR test back then and who was looking at it, in layman's terms?

Christian Drosten: This test was done at a time when we didn't even have this virus in the country or in the laboratory. And we have started developing it based on the closely related SARS coronavirus. But this has nothing to do with the common cold coronaviruses. Genetically, that's very far. And we did two tests. In fact, we actually did a whole series of tests—candidate tests. And they were made on the basis of the old SARS coronavirus and a huge diversity of bat coronaviruses, i.e. the closest relatives that are all in the same virus type. And we've done tests that would detect a number of these coronaviruses. So these animal corona viruses, bat corona viruses, would also be recorded. And the old SARS coronavirus and then with some probability the new one too. And then the sequence of the new coronavirus came out. Then we matched that.

Korinna Hennig: From China.

Christian Drosten: From China, from colleagues, but only theoretically as sequence information. Then we took the two tests from our candidate tests that are particularly good for this new virus. We then further validated them, with the University of Hong Kong, the University of Rotterdam, the national public health organization in London and our own patients. A very, very large validation study has been done. I would have to open it on my computer now to go back to the numbers. But we have large numbers of real patient samples—with known positive evidence of other coronaviruses and also every other cold virus we know, and a whole number of them for each individual virus—a whole number of patient samples, that is, hundreds of samples with other coronaviruses and other cold virus, we tested in this test. And not once has there been a false positive reaction. So this test does not react against any other human coronavirus and against any other human cold virus.

It's true, but of course that is completely misleading information, in theory this test would react against the old SARS coronavirus. But this has not happened in humans for 16 years. And theoretically, this test would also react against a whole range of bat coronaviruses, but they don't exist in humans either.[4]

That last paragraph nails it. The common cold viruses are excluded, and the apparent a-specificity of the test, which is designed intentionally, can do no harm, for humans don't suffer from SARS-CoV or bat viruses at the moment.

Drosten also touches on the financial gains he might have received by distributing this test (remember that the Review Report stressed this "conflict of interest" aspect):

Christian Drosten: And the kind of technical validation is at such a high level, and we already published it in January, it was one of the first scientific publications ever about this new virus, that an incredibly large number of companies, not only in Germany, but in the all over the world, has started to transfer this test immediately into commercial validated test systems because of this good validation data. And at the same time, the World Health Organization immediately put this test protocol public on their side so that all public health agencies can use it.

And we immediately started distributing the essential material around the world. We started right away in mid-January, incidentally, free of charge, so we're involved in a research project that is being paid for by the European Union. They give us support for a personnel position that packs these packages that we send worldwide for RNA material. And the recipients on the other hand do not have to pay an allowance for the transport costs to us, but to this EU project (which, by the way, is coordinated at the University of Marseille).

Korinna Hennig: So, you don't make any money with it.

Christian Drosten: We don't earn a cent. On the contrary, we pay a lot on top of it. Fortunately, we are supported by public research funding from the European Union and, more recently, from the Bill Gates Foundation, Bill & Melinda Gates Foundation. But these are research funds that are specifically there for this purpose. We don't do any other research with it, but basically just pack packages with it. So we don't earn a penny, we pay more because we didn't have this research funding at the beginning. We just had to push it out of the postage because otherwise nobody would have done anything....

Korinna Hennig: So transparency not only in research, but also in the figures.

Here's a table summarizing the whole production and test flow of the Corman-Drosten PCR test:

To summarize: the Corman-Drosten test was based on a full SARS-CoV-2 genome received from Chinese researchers, who had assembled it within days. Given their expertise with SARS-CoV the Drosten team re-used an existing test protocol for this previous SARS virus, but also added specifics that would makes sure SARS-CoV-2 was matched. So there are generic and specific elements to this test. However, it is not so generic that viruses other than animal bat or SARS viruses are matched as well, and it can distinguish between SARS-CoV and SARS-CoV-2. As a proper test for this new virus should be able to do. And even if that SARS-CoV-2 element was skipped, the SARS-generic test would still make do because SARS-CoV is no longer circulating.

None of these basic facts were picked up by the two authors/contributors of the Review Report, who feature so erroneously as "courageous scientists" in the Naomi Wolf video interview. False heroism, if you ask me.

HOW A CONSORTIUM OF NON-EXPERTS IS BUILT

Andreas Beyer

The main objection of the Review Report main authors to the response from Eurosurveillance seemed to be that it did not address their many points of criticism. Well, it turns out that that work has already been done. On Researchgate I found a long article by Andreas Beyer, which reviewed the Corman-Drosten Review Report paper point-by-point.[5] Beyer is currently a university professor in molecular biology at the Westfälische Hochschule in Recklinghausen, Germany. In this role he covers the fields of: standard methodology of molecular biology, DNA sequencing, PCR, biochemistry and computer-assisted sequence analysis. His competence by far exceeds those of most "top scientists in the life sciences" of the Consortium that published the Review Report.

As Beyer drily remarks when commenting on the "expertise" of the 22 authors/proofreaders of the Review Report: with few exceptions, none of them are molecular biologists with PCR-related experience. Now this has often been taken to involve unwarranted ad hominem attacks on the Consortium members, but that is most definitely not the case. Qualifications do matter here. It is highly relevant. With the exception of first author Pieter Borger and Kevin McKernan, none of these luminaries have evidenced any practical experience or theoretical expertise with this specialized field, not even the last author (who normally has a senior and supervising role in scientific articles), Ulrike Kämmerer, who specializes in cancer and nutrition!

Here's Beyer's breakdown of the Consortium members:

The main, or at least the last author of the Review Report paper, Ulrike Kämmerer, recently gave a rather curious justification of the doubtful expertise of the the Consortium members:[6]

About the authors [of the Review Report] it was always said that we weren't active virologists who deal with SARS-CoV-2. PCR is a completely normal, mundane, routine method in every laboratory. I don't have to be a top virologist or anything on the contrary: the people who do their daily work with it, see where these technical flaws are much faster than someone who hovers somewhere above.
I don't have to be a bricklayer to see a wall is skewed. (p. 75)

Yet, how many of these 22 "experts" have this day-to-day experience with PCR testing? It is precisely those PCR specialists, like Andreas Beyer, Ian MacKay and others, who posses this expertise, and who have raised stern objections to this whole retraction project! It is precisely the bricklayers who have to be listened to here.

In fact, this whole notion of an "INTERNATIONAL CONSORTIUM OF SCIENTISTS IN LIFE SCIENCES (ICSLS)" which produced the Review Report is an inflated charade when it comes to relevant technical PCR expertise. In my opinion, Borger and McKernan could have co-authored it with more, not less credibility. And even then, as Beyer comments: Borger is currently a "research associate" at the Christian-creationist organization Wort und Wissen, which has no research division or laboratory, and McKernan is more of a sales manager for Medical Genomics (and specializing in the genomics of... cannabis. Hey, I am from Amsterdam).

Actually, in a recent interview the second author of the retraction paper, Bobby Malhotra, gives us some insight in how the "Consortium" came together:

On a day when I was very upset [after his contract was not renewed in Q4, 2020], I created a mega thread on Twitter with 124 tweets. In "Corona Ausschuss Nr. 22", Corona Committee No. 22, Prof. Dr. Ulrike Kämmerer had explained the problem of Drosten PCR tests. I linked this with my knowledge and tried to explain it for the beginner on Twitter—a mixture of corruption, bioinformatics and the PCR problem. This thread pretty much hit home.
This is how I came across Dr. Pieter Borger, who was already critical on ResearchGate at the same time. At some point he wrote to me, Mr. Malhotra, do you want to join me, I want to write a retraction for the Drosten paper. Then I had to open up to him that I am not a classical scientist at all, but a digital artist and self-taught bioinformatician. He was very surprised why I was able to talk to him at all about these issues. I then told him basically the same story I told you. After a meeting with Pieter Borger and Ulrike Kämmerer, everything was actually clear relatively quickly. We split up, asked our scientific circles and gathered 22 scientists... So we went on a search with Kevin McKernan. He's sort of our "Mister Technical Details," the technical details man, the "Mister PCR" of the scientific literature.
From him we know that this Charité [Corman-Drosten] primers & probes design is actually pretty garbage. We then put such technical details into the Addendum. For example, the RdRp gene has too low a sensitivity. The point is that you have to have a certain kind of sensitivity to be really sure that this result is true. It just isn't.[7] (emphasis added)

As I wrote in Part 20, the reduced sensitivity of one part of the Corman-Drosten test is widely known, and hardly a reason to demand a retraction. I would say "the first pancake always fails" and the more pancakes we bake, the better they become.

A POINT-BY-POINT REBUTTAL OF BORGER ET AL.

Beyer calls the tone of the Review Report paper “presumptuous and insolent”. But on to the Review Report itself and its main points of criticism directed at the Corman-Drosten PCR protocol. I restrict myself to the SUMMARY CATALOGUE OF ERRORS FOUND IN THE PAPER of the Review Report, and will quote Beyer's comments in full:

There are other pertinent points raised in the Beyer paper, but I leave it to you to pursue this further, if that's your interest. But as you can see from the above, there is, again, a world of difference between the belligerent and accusative mood of the Corman-Drosten Review Report and the informed opinions of experienced scientists, who know that what works in theory doesn't always do so in practice. As we say in Dutch: "The best helmsmen stand on shore" (which seems to be equivalent to: "Bachelors' wives and maidens' children are well taught", source: Heywood, 1546).

Beyer is even more blunt in his final conclusions:

The authors claim to be able to refute the Drosten paper on scientific grounds.

However, if you want to criticise a scientific paper, you should do this in the form of another scientific paper, published in a scientific journal with peer review (!) and not in the form of a private www-domain. This fact alone already renders this "peer review" highly dubious. Hence, as long as the text by Borger et al. has not been checked and accepted by a scientific journal (which will not happen due to its blatant errors) it is nothing than expression of opinion of some laypeople.

Second, the fact that the authors did not perform a single experiment but argue alone on basis of "theoretical considerations" is more than questionable.

Third, the authors have no expertise in analytic / diagnostic PCR systems. There is only a single virologist among them—Prof. Ohashi. And he has no experience in corona research. The ignorance of the authors can easily be recognised by the flawed critique they utter. Some of the mistakes they make even are beginner's mistakes. It is nothing but imprudence to criticise on such weak grounds a peer-reviewed paper from an internationally well-respected scientific group.

Fourth, the respective qPCR-system has now been used worldwide since several months. If it was faulty, if it had any of the claimed impairments it would have been criticised long ago. In contrary—meanwhile there have quite a few comparisons of existing PCR assays been published (z. B. Afzal 2020, Matheeussen et al. 2020, Nalla et al. 2020, Vogels et al. 2020). No one has found severe drawbacks in the Corman-Drosten assay (just a less sensitive RdRp-assay in comparison to others, that was all).

Fifth, it can easily be shown that all critical points submitted by the authors implode under closer inspection. However, quite a bit technical knowledge—not available for laypeople—is necessary to see through this flawed argumentation. And so, this "paper" already has become famous among conspiracy theory proponents, anti-vaccationists and creationists: Audacter calumniare—semper aliquid haeret... [slander boldly, something always sticks].

Last, Borger et al. were given the chance to comment on my arguments and to defend themselves. They kept silent.[See their response in Appendix 2]

In all, this "peer review" is at best pseudoscience—if not conspiracy theory and slander.

In the meantime, Bobby Malhotra, who we met in the video and who features as the second author of the Review Report—and is for sure the most vindicative and the least qualified of all, being a 3D artist—has already announced an official reply to Beyer's paper, again losing all sense of perspective and proportion (there we have the ad hominems again!).

So it's "totally wrong" vs. "utter nonsense"? Not a good climate for productive debate. Two paradigms or false equivalence? "Free and reliable science" or "political and pseudoscience" (as Pieter Borger frames it)? I would not put my bet on the Consortium. They will predictably complain, "Yes, but what about our Addendum?" But if the theoretical foundations of their Review Report are so problematic, why bother?

Stay tuned. And stay safe.

Appendix 1 : Dan Wilson's Debunk of the Retraction Request

Dan Wilson, a PhD scientist in molecular and structural biology, has a YouTube channel "Debunk the Funk with Dr. Wilson", on which I found this debunk of the Borger et al. paper. He has also debunked Kaufman, Cowan, the Chromosome 8 canard, Michael Yeadon, the lab orgin theory, and many other topics covered in THE CORONA CONSPIRACY, so he's definitely a kindred spirit.

He concludes: why do we find positives only in countries that are still impacted by the virus, with many hospitalized cases and deaths, and not in countries were they have seemed to have beaten the virus (even though wide-scale testing has continued)?

Ultimately this critique [by Borger et al.] is nothing more than conspiracy theories with an illusion of expertise behind it. It offers really no helpful critiques, nothing of scientific substance to this conversation and only serves to galvanize the COVID-denying movement.

Ironically the more people deny COVID the more dangerous the virus gets.

Another astute observation by Wilson: "this Corman-Drosten paper reflects both the good and the bad parts of science during this pandemic." He recommends reading Ed Young's piece for The Atlantic: "How Science Beat the Virus, and what it lost in the process".[8] From which:

[T]he COVID-19 pivot has also revealed the all-too-human frailties of the scientific enterprise. Flawed research made the pandemic more confusing, influencing misguided policies. Clinicians wasted millions of dollars on trials that were so sloppy as to be pointless. Overconfident poseurs published misleading work on topics in which they had no expertise. Racial and gender inequalities in the scientific field widened.

Appendix 2 : A "Refutation of Andreas Beyer's criticism"

A 22 page "refutation" of Beyer's paper has been published on the ICSLS website in mid February 2021.[9] Its main objection was: Beyer has not read our Addendum. Well, the Review Report should stand on its own merit, and should not need any Addendum to strengthen its case, in my opinion, Beyer finds flaws in the Report which need to be addressed. (Another matter is if the Addendum really provides empirical support for the thesis of the Review Report, or if it presents a more nuanced picture).

Furthermore, it is argued that Beyer hasn't published much scientific articles in the relevant field, so his "ad hominem" attack on the Consortium members is misplaced. However, Beyer seems to have a lot of hands on experience when it comes to PCR, contracy to most of the Consortium members. (As an aside, Beyer has also written about creationism and evolution, so that overlaps with Borger's fields of interest). On Researchgate the two gentlemen corresponded briefly (11 February 2021). Borger asked "Why is it not allowed to express scientific concerns when a paper contains flaws?". Beyer's reply: "Good question! Exactly this is what I do with the Borger text."

One interesting point raised by Borger et al., is that, in their opinion (also voiced by Ulrike Kämmerer[6]), there was no need for a Drosten test protocol at all, because the Chinese researchers, who where the first to produce the full genome of SARS-CoV-2, already had a test.

There was no pandemic situation at the given timeframe but an outbreak of pneumonia in China with 6 deaths in Hubei province, as stated and referenced in our main review report. The chinese scientists had everything of particular interest already available [5 articles by Chinese researchers are mentioned]:

• the alleged isolated virus (from primary patient samples),
• the sequences,
• their own PCR protocol-design.

There was no actual need for any hurry in Europe, the authors just could have asked the Chinese colleagues about their findings and the corresponding raw data. Why did they assume the chinese scientists would need any help with a PCR-protocol design out of Europe? While Corman et al. designed their flawed PCR protocol-design, the chinese CDC had already sequenced the alleged agent, generated the starting-point for a phylogenetic tree and established a diagnostic RT-qPCR in the first week of January. (p. 8)

Of course, the quality of the Chinese tests is relevant here, and not discussed in this "Refutation". Ironically, in conspiracy circles China is often portrayed as the Evil Empire, so at least this is a nice admission to have on record. (Notice the word "alleged", which leaves room for speculation about the real cause of COVID-19). And in retrospect, blaming the Drosten team for assuming a worldwide pandemic sounds a bit odd. They were very prescient indeed, given the two millons deaths a year later.

Though these Borger vs. Beyer exchanges still look like trench warfare, with no party conceding any ground, it could be the start of a more meaningful discussion. Beyer plans to address the Addendum when his busy teaching work schedule permits.

Appendix 3: Stephen Bustin On the nature and value of PCR testing

In a recent article (Feb. 2021), PCR authority Stephen Bustin (who was one of the reviewers consulted by Eurosurveillance in its evaluation of the Review Report and is the author of the authoritative handbook A-Z of Quantitative PCR, 910 pages, 2004), reflects on the nature and value of PCR testing. Here's the abstract:

Although molecular testing, and RT-qPCR in particular, has been an indispensable component in the scientific armoury targeting SARS-CoV-2, there are numerous falsehoods, misconceptions, assumptions and exaggerated expectations with regards to capability, performance and usefulness of the technology. It is essential that the true strengths and limitations, although publicised for at least twenty years, are restated in the context of the current COVID-19 epidemic. The main objective of this commentary is to address and help stop the unfounded and debilitating speculation surrounding its use.[10]

He also mentions the Corman-Drosten test in passing, and gives the following balanced judgement. Though the feedback given to Eurosurveillance about the Corman-Drosten Review Report has been not made public, I am sure Bustin had it in mind when he wrote these lines:

This test, targeting three SARS-CoV-2 genes, was not ideal as primer and probes were not optimised and it was not as sensitive as later iterations. However, the assay worked and was specific and demonstrated astounding sagacity and selflessness by the scientists involved, as well as the remarkable speed with which PCR-based tests can be developed and put into practice. Since then a large number of additional tests and improved protocols have been created by individual research groups and companies in many countries targeting a range of SARS-CoV-2 specific sequences, some detecting multiple targets, others able to detect its presence in crude samples, and yet others generating results in minutes. This means that we have a whole panoply of kits available using different reverse transcriptases, Taq polymerases and buffer combinations, all of which can detect SARS-CoV-2.[10] (emphasis added)

Remarkably, where the authors of the Corman-Drosten Review Report framed the Corman-Drosten test negatively within a negative approach to testing for COVID-19, Bustin does the exact opposite. And even though he acknowledges some shortcomings regarding this early RT-qPCR test, he puts it firmly in the context of a strong pro-testing approach aiming at continuous improvement of the various ways of testing at our disposal. No need for any hysterical conclusions.

Appendix 4: Andreas Beyer's reply to Borger et al.'s Report and Addendum

In a 8500 words essay, prof. Andreas Beyer has offered a devastating critique of both the Review Report and the Addendum of the Borger-Kämmerer team.[11] He goes into great detail to expose the shortcomings of these texts and their clear agenda to discredit science:

Read on ResearchGate.Net

Here, a general problem of the Borger-Kämmerer alliance becomes obvious: It is not enough—and it is not science—to put some sequence data into some analysis software and enjoy the output. One has to understand and interpret the output and this requires well-funded theoretical knowledge and practical skills—obviously not available in the Borger-Kämmerer alliance...

To get to the point: Indeed, the Corman-Drosten qPCR system "version 1.0" was "immature" which no one denies. However, already "version 2.0" was fully functional long before the Borger-Kämmerer text was launched (!)... Various tests have shown the weak points in "version 1,0", but no one drew the conclusion that it is completely unsuitable as claimed by the Borger-Kämmerer group...

Another critical point is the way the Borger-Kämmerer group utilises scientific literature. They pick out whatever seemingly supports their argumentation and ignore the rest. And in doing so citations are sometimes presented out of their context.

And he concludes:

The Borger-Kämmerer text is pseudoscience, it is full of misconceptions, errors and flaws. Therefore it is ignored by experts for good reason. The impact it had in public consciousness, however, is fatal. Borger reported on Twitter more than 30 Million views of his "Report" (March 2021) [now 50 million]. Hence I ask all colleagues please to spread this essay for at least a little bit of counterbalance.

The authors of the ICSLS Consortium have specifically expressed their wish for scientists to reflect on their studies of the Corman-Drosten test. Methinks they can't wish for a better treatment than a critical review.

I leave it to you to dive into the dirty details by reading the essay on ResearchGate.

NOTES

[1] Victor M Corman et. al., "Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR", PMC, www.ncbi.nlm.nih.gov, (Euro Surveillance, 2020 Jan 23).

[2] Pieter Borger et. al., "Review report Corman-Drosten et al. Eurosurveillance 2020", External peer review of the RTPCR test to detect SARS-CoV-2 reveals 10 major scientific flaws at the molecular and methodological level: consequences for false positive results, November 27, 2020.

[3] Naomi Wolf, "PCR Lab Visit: Whistleblowers Kevin McKernan, Bobby Malhotra Explain Why COVID Tests are 'Garbage'", YouTube, 24 Jan 2021.

[3a] Coronaviridae Study Group of the International Committee on Taxonomy of Viruses, "The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2", Nat Microbiol. 2020; 5(4): 536-544.

[4] Korinna Hennig, "Coronavirus Update, Folge 16", NDR, March 18, 2020.

[5] Andreas Beyer, "Pseudowissenschaftliche Kritik an einem von der Berliner Charité veröffentlichten Coronavirus (SARS-CoV-2)-Test, publiziert von Peter Borger und Koautoren / Pseudoscientific criticism on a Coronavirus (SARS-CoV-2) test published by Peter Borger and coauthors-PCR-Borger-Report", January 2021, www.researchgate.net (PDF). A nice summary in German can be found here: Andreas Beyer, "COVID-19 und Kreationismus: Widerlegen Borger et al. die Drosten-PCR? Die unheilige Allianz der Verschwörungstheoretiker", www.ag-evolutionsbiologie.net, January 23, 2021.

[6] "Illa", Das PCR-Desaster, Genese und Evolution des "Drosten-Tests", Verlag Thomas Kubo, 2021 (PDF). Kämmerer's quote comes from a partial transcript from: 38. Sitzung zum Thema "Angriff auf Mensch und Gesellschaft" (corona-ausschuss.de, February 5, 2021), which is inluded in this book.

[7] Aya Velázquez, "We are in the middle of an information war", medium.com, Febuary 3, 2021.

[8] Ed Young, "How Science Beat the Virus, and what it lost in the process", The Atlantic, December 14, 2020.

[9] "Refutation of Andreas Beyer's critisism", cormandrostenreview.com, no date (mid February 2021). The page is now password protected and apparently still work in progress (Version 2). Version 1 is archived here: https://archive.is/UevlP

[10] Stephen Bustin et al., "COVID-19 and Diagnostic Testing for SARS-CoV-2 by RT-qPCR — Facts and Fallacies", International Journal of Molecular Sciences, 28 February 2021 (PDF).

[11] Andreas Beyer, "Borger & Kämmerer, Corona & qPCR, Pseudoscience & Conspiracy Theory Revisited - an Analytical Essay", ResearchGate, May 2021.